Process for preparing optically active tetrahydro-2-furoic acid

Details Process for preparing optically active tetrahydro-2-furoic acid Process for preparing optically active tetrahydro-2-furoic acid

1990-02-06

1991-01-15

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30724

Patent

active

049855751

ABSTRACT:
A process for preparing an optically active tetrahydro-2-furoic acid is disclosed. The process comprises (i) reacting (.+-.)-tetrahydro-2-furoic acid with an optically active amine resolver of the following formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group and R.sub.2 represents an alkyl group or ar aryl group, provided that R.sub.1 and R.sub.2 are different from each other, thus producing an optically active diastereomer salt, and (ii) decomposing the diastereomer salt. According to the process, a high purity, optically active tetrahydro-2-furoic acid can be prepared at a high yield using an amine resolver. The amine resolver can be recovered at a high yield and high purity.

REFERENCES:
patent: 4950772 (1990-08-01), Nohira et al.
Nohira et al., Chemical Abstracts, vol. 110 (1989) 94589p.

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