Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1986-03-31
1990-02-06
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435136, 435280, 435197, 435110, 435839, 435897, 435830, 435813, 435874, 435925, 435921, 435911, 435170, C12P 1710, C12P 104, C12N 918, C07P 4100
Patent
active
048988227
ABSTRACT:
A process for preparing optically active indoline-2-carboxylic acid by an optical resolution, which comprises subjecting a racemic ester of (R,S)-indoline-2-carboxylic acid having the general formula [(R,S)-I] to the action of an enzyme or a microorganism having a stereo-selective esterase activity, which is capable of asymmetrically hydrolyzing the racemic ester [(R,S)-I] to give optically active indoline-2-carboxylic acid having the formula [II*] so as to produce the hydrolysis product, i.e. optically active indoline-2-carboxylic acid [II*] and an unreacted optically active ester of indoline-2-carboxylic acid having the general formula [I*], isolating each optically active form, and further, if necessary, hydrolyzing the obtained optically active ester [I*] to give an optical antipode of the acid [II*].
According to the process of the present invention, optically active indoline-2-carboxylic acid with a high optical purity can be prepared in a simple process with a good yield.
REFERENCES:
patent: 4486241 (1984-11-01), Schouten
Ghisalba et al., Nachri Chem. Tech. Lab. 34, pp. 973-982, 1986.
Patent Abstracts of Japan, vol. 10, No. 269 (C-372)[2325], 12th Sept. 1986; & JP-A-61 92 595, 596.
Patent Abstracts of Japan, vol. 11, No. 141 (C-421)[2588], 8th May 1987; & JP-A-61 282 093.
Asada Masanori
Hamaguchi Shigeki
Katsuki Hidetoshi
Nakamura Yoshio
Ohashi Takehisa
Kanegafuchi Kagaku Kogyo & Kabushiki Kaisha
Marx Irene
Warren Charles F.
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