Process for preparing optically active cyano compound

Details Process for preparing optically active cyano compound Process for preparing optically active cyano compound

1987-12-10

1991-03-26

Chaudhuri, Olik

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549495, 558351, C07D33312, C07D33320, C07D30702, C07C25300

Patent

active

050030833

ABSTRACT:
A novel process for effectively preparing an optically active cyanohydrin comprising asymmetrically cyanating an aldehyde by reacting the aldehyde with a cyanating agent in the presence of a titanate of an optically active tartaric acid derivative.

REFERENCES:
patent: 4174459 (1979-11-01), Sakamoto
Minamikawa et al., "Asymmetric Hydrocyanation of Aldehydes Using Chiral Titanium Reagents", Bull. Chem. Soc. Jpn., vol. 61, 4379-4383 (1988).
Tetrahedron Letters, "Asymmetric Synthesis via Chiral Acetal Templates 7.1 Further Studies on the Cyanation Reaction. The Use of Acetals Derived From Diols With One Chiral Center", vol. 25, No. 6, 1984, pp. 591-594, Pergamon Press Ltd., GB; V. M. F. Choi et al.
Journal of the Chemical Society, Chemical Communications, No. 5, 1981, pp. 229,230; J.-I. Oku et al.; "Asymmetric Cyanohydrin Synthesis Catalysed by a Synthetic Cyclic Dipeptide".
Chemistry Letters, No. 10, Oct. 1987, pp. 2073-2076, The Chemical Society of Japan; K. Narasaka et al.; "Asymmetric Hydrocyanation of Aldehydes with Cyanotrimethylsilane Promoted by a Chiral Titanium Reagent".
Journal of the American Chemical Society, vol. 102, No. 18, 27th Aug. 1980, pp. 5974-5976, American Chem. Society; T. Katsuki et al.; "The First Practical Method for Asymmetric Epoxidation".

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