Process for preparing optically active arylacetic acid derivativ

Details Process for preparing optically active arylacetic acid derivativ Process for preparing optically active arylacetic acid derivativ

1987-07-09

1988-08-09

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562490, C07C 5730, C07C 6336

Patent

active

047629487

ABSTRACT:
An optically active arylacetic acid derivative of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are each an hydrogen atom, a lower alkyl group or a phenyl group; and Ar is a group of the formula: ##STR2## a group of the formula: ##STR3## wherein R.sub.3 and R.sub.4 are the same or different and are each a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a difluoromethoxy group, a trifluoromethyl group or a phenyl group is prepared in good conversion and optical yield by asymmetrically reducing an ethylenically unsaturated compound of the formula: ##STR4## wherein R.sub.1, and R.sub.2 and Ar are the same as defined above with hydrogen in the presence of a metal catalyst modified with a ligand selected from the group consisting of a specific optically active metallocenyl phosphine derivative and a specific optically active binaphthyl derivative.

REFERENCES:
patent: 4119652 (1978-10-01), Knowles
patent: 4198510 (1980-04-01), Shioiri et al.
patent: 4409397 (1983-10-01), Paxson
patent: 4440936 (1984-04-01), Riley

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