Process for preparing optically active...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S076000, C549S077000

Reexamination Certificate

active

07119211

ABSTRACT:
Disclosed is a process for commercial preparation of 3-(methylamino)-1-(2-thienyl)propan-1-ol (hereinafter abbreviated as “MMAA”) of the formula below:The process is carried out by the diastereomeric salt formation method using optically active mandelic acid or its derivatives, or an optically active tartaric acid derivative as the resolving agent. The product compound, diastereomeric satls, is useful as the intermediate for producing pharmaceuticals, such as duloxetine.

REFERENCES:
patent: 6723745 (2004-04-01), Nishi et al.
patent: 6753344 (2004-06-01), Talley et al.
patent: 6800759 (2004-10-01), Valeriano et al.
patent: 6992110 (2006-01-01), Kranzler et al.
patent: 7005452 (2006-02-01), Deregnaucourt et al.
patent: 7045341 (2006-05-01), Kamal et al.

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