Process for preparing optically active 4-mercapto-2-pyrrolidone

Details Process for preparing optically active 4-mercapto-2-pyrrolidone Process for preparing optically active 4-mercapto-2-pyrrolidone

1995-03-24

1996-02-27

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

548544, 548530, 562 41, 562556, C07C30914, C07C32325

Patent

active

054950120

ABSTRACT:
A process for preparing an optically active 4-mercapto-2-pyrrolidone derivative of the formula [I]: ##STR1## wherein R.sup.1 is a hydrogen atom or a protecting group and R.sup.2 is a hydrogen atom or a protecting group, which comprises subjecting racemic 4-amino-3-mercaptobutyric acid or a salt thereof to optical resolution by using 1-(trichlorophenyl)ethanesulfonic acid, followed by subjecting the product to cyclization reaction after protecting the functional groups thereof, if necessary, and further optionally removing the protecting groups therefrom. The present process is industrially advantageous than conventional processes for preparing optically active 4-mercapto-2-pyrrolidone derivatives which are useful as an intermediate for various medicines such as carbapenem antibacterial agents.

REFERENCES:
patent: 5153187 (1992-10-01), Iwasaki et al.
Hayashi et al, Chemical Abstracts, vol. 77 (1972) 151679.
Ishikawa et al, Chemical Abstracts, vol. 108 (1988) 195847.
Pinza et al, Cyclic Gaba-Gabob Analogues . . . , Il Farmaco--Educational Science, vol. 33, pp. 130-141, 1978.
Chemical Abstracts, vol. 117, No. 21, 23 Nov. 1992, Columbus, Ohio, US; Abstract No. 212225m, '2-(2-Oxopyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarba pen-2-em-3-carboxylic acid pivaloyloxymethyl ester, & JP-A-04 103 584 (Tanabe Seiyaku K.K.) 6 Apr. 1992.
Database WPI, Section Ch, Week 9346, Derwent Publications Ltd., London, GB; Class B05, AN 93-365196 & JP-A-5 271 169 (Tanabe Seiyaku Co) 19 Oct. 1993.
Database WPI, Section Ch, Week 8445, Derwent Publications Ltd., London, GB; Class B05, AN 84-278320 & JP-A-59 170 057 (Tanabe Seiyaku KK) 26 Sep. 1984 .

Affiliated with

Also associated with

Rating

Process for preparing optically active 4-mercapto-2-pyrrolidone does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing optically active 4-mercapto-2-pyrrolidone , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing optically active 4-mercapto-2-pyrrolidone will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1680112