Process for preparing optically active 3-hydroxypyrrolidine deri

Details Process for preparing optically active 3-hydroxypyrrolidine deri Process for preparing optically active 3-hydroxypyrrolidine deri

1991-04-09

1992-09-01

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546281, C07D20712

Patent

active

051440423

ABSTRACT:
A process for preparing optically active 3-hydroxypyrrolidine derivatives useful as intermediates represented by formula (III): ##STR1## wherein Q represents a substituted or unsubstituted phenyl group; and * indicates an asymmetric carbon atom, comprising reacting an optically active 4-halo-3-hydroxybutane derivative represented by formula (I): ##STR2## wherein * is as defined above; R.sup.1 represents a lower alkyl group or a substituted or unsubstituted phenyl group; and X represents a halogen atom, with a benzylamine derivative represented by formula (II):

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