Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2006-11-28
2006-11-28
Marx, Irene (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S123000, C435S170000
Reexamination Certificate
active
07141412
ABSTRACT:
A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding pyrrolidines, respectively, by use of a bacterium having hydroxylation activity, or a prokaryotic host-organism having the gene(s) necessary for the hydroxylation, or an enzyme having hydroxylation activity derived therefrom. The bacterium may be selected from strains having alkane hydroxylases, strains degrading alkanes or mono-alicyclic compounds, or strains from the generaPseudomonas, Mycobacterium, Corynebacterium, Nocardia, Sphingomonas, Gordona, Rhodococcus, Bacillus, Streptomyces; Sebekia andMethylococcus.
REFERENCES:
patent: 1140055 (1996-04-01), None
patent: WO98/23768 (1998-04-01), None
Parishakov, et al.,Microboial transformations of nitorgen-containing heterocyclic compounds,XP-002100836, Jan. 4, 1993.
Li Zhi
Witholt Bernard
Eidgenossische Technische Hochschule Zurich
Hoffmann & Baron , LLP
Marx Irene
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