Process for preparing optically active 3-hydroxybutane derivativ

Details Process for preparing optically active 3-hydroxybutane derivativ Process for preparing optically active 3-hydroxybutane derivativ

1990-08-13

1992-07-07

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435130, C12P 1100

Patent

active

051282640

ABSTRACT:
A process for preparing optically active 1-substituted-3-hydroxybutane or its derivatives of formula (II) or (III) ##STR1## comprising treating an ester derivative of racemic 1-substituted-3-hydroxybutane of formula (I), ##STR2## wherein R.sub.1 is chloromethyl group or methyl group and R.sub.2 is p-toluenesulfonyloxy group or phenylthio group, provided that when R.sub.1 is methyl group R.sub.2 is not p-toluenesulfonyloxy group, with a lipase derived from the genus Pseudomonas.

REFERENCES:
patent: 4745066 (1988-05-01), Hamaguchi et al.
patent: 4791059 (1988-12-01), Nakao et al.
Chinchilla et al., Tetrahedron: Asymmetry 1:575-78 (1990).
Journal of the American Chemical Society, vol. 104, 1982, Washington, D.C. CH.-S. Chen et al. "Quantitative Analyses of Biochemical Kinetic Resolutions of Enantiomers" pp. 7294-7299 *Totality*.

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