Process for preparing optically active 2-halo-1-phenyl ethanol

Details Process for preparing optically active 2-halo-1-phenyl ethanol Process for preparing optically active 2-halo-1-phenyl ethanol

1986-04-10

1989-08-15

Warden, Robert J.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435156, 435161, 435171, 435911, 435921, 435933, 435940, C07P 4100

Patent

active

048574686

ABSTRACT:
A process for preparing optically active 2-halo-1-phenyl ethanol having the general formula [I*]: ##STR1## wherein X is a halogen atom, by asymmetrically reducing 2-halo-acetophenone having the general formula [II]: ##STR2## wherein X is as above, to give optically active 2-halo-1-phenyl ethanol, (R)-form or (S)-form, employing the microorganism. ##STR3## According to the present invention, optically active 2-halo-1-phenyl ethanol can be prepared with a good optical purity and yield in a simple process.

REFERENCES:
patent: 3076750 (1963-02-01), Muys et al.
patent: 4396715 (1983-08-01), Labows, Jr. et al.
Chemical Abstracts, vol. 95. No. 7, p. 521, No. 113491m, Sep. 1981.
Chemical Abstracts, vol. 107, No. 7, p. 603, No. 54741m, Aug. 17, 1987.
J. Org. Chem. 45, 3352, (1980).
Tetrahedron Letters 22, 2527, (1981).
J. Chem. Soc., Chem. Comm., 1975, 400, (1975).

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