Process for preparing optically active 2-arylpropionic acids

Details Process for preparing optically active 2-arylpropionic acids Process for preparing optically active 2-arylpropionic acids

1990-08-30

1992-03-17

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548217, 548444, 548572, 549 58, 562460, 562461, 562462, C07B 5700

Patent

active

050970640

ABSTRACT:
This invention relates to a process for preparing an optically active 2-arylpropionic acid of general formula (I), by the hydrogenation, in a heterogeneous aqueous-organic medium, of a 2-arylacrylic acid of general formula (II) in the presence of a catalyst consisting of a rhodium derivative and a water-soluble chiral ligand.
In the general formulae (I) and (II), Ar represents an optionally substituted monocyclic or polycyclic aromatic radical or an optionally substituted aromatic heterocyclic radical: ##STR1##

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Gazzetta Chimica Italiana, vol. 110, No. 2,3, (Feb.-Mar. 1980), pp. 123-127.
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