Process for preparing optically active 2-aminopropanal

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564453, 564454, 564455, 564462, 564468, 564502, 564503, 564506, C07C22302, C07C22712, C07C22704

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active

053997638

ABSTRACT:
A process for preparing an optically active 2-aminopropanal through oxidative cleavage of the corresponding optically active 3-amino-1,2-butanediol of the following formula (2): ##STR1## wherein R1 is a hydrocarbon group having 3 to 6 carbon atoms; R2 and R3 are each a hydrogen atom, or separately or together represent an N-protecting group; and the configuration at the *1 position is S or R. An optically active 2-aminopropanal of high purity can be obtained in a high yield by the process.

REFERENCES:
patent: 4711958 (1987-12-01), Iizuka et al.
patent: 5276190 (1994-01-01), Boesten et al.
Journal of Organic Chemistry, 52, 1487-1492 (1987).

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