Process for preparing optically active 2,3-dihydrobenzofuran...

Details Process for preparing optically active 2,3-dihydrobenzofuran... Process for preparing optically active 2,3-dihydrobenzofuran...

2008-09-02

2008-09-02

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S454000, C549S467000, C549S491000

Reexamination Certificate

active

11054371

ABSTRACT:
A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound:[wherein R1and R2are each hydrogen or an optionally substituted hydrocarbon group; R3is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

REFERENCES:
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J. Jacques et. al,Enantiomers, Racemates, and Resolution, (1981), pp. 387-388, John Wiley & Sons, New York, USA.

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