Process for preparing oligonucleotides using silyl-containing di

Details Process for preparing oligonucleotides using silyl-containing di Process for preparing oligonucleotides using silyl-containing di

1993-07-29

1997-03-25

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 556436, 556449, C07H 100, C07H 2100

Patent

active

056146213

ABSTRACT:
Synthetic processes are provided wherein substituted silylalkyl phosphoramidites serve as coupling reagents for preparing phosphate, phosphorothioate, and other phosphorous-containing covalent linkages. Also provided are synthetic intermediates useful in such processes.

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patent: 5113005 (1992-05-01), Celebuski
Celebuski, et al., "Synthesis and Utility of a DNA Phosphorylating Agent Based on 2-(Triphenylsilyl)ethanol", J. Org. Chem., 57, (1992).
Honda, et al., "2-Diphenylmethylsilylethyl Group as a New Protecting Group of Internucleotidic Phosphates in Oligonucleotide Synthesis", Tetrahedron Letters, (1981), 2093-2096.
March, "Advanced Organic Chemistry", John Wiley & Sons, New York, Third Edition, (1985), Chapter 1, pp. 16-18 and Chapter 9, pp. 237-239.
Streitwieser and Heathcock, "Introduction to Chemistry", Second Edition, (1981), Chapter 15, 437-440.
Takaku, et al., "Use of 1,1,1,3,3,3-Hexafluoro-2-Propyl Protecting Group in the Synthesis of DNA Fragments Via Phosphoramidite Intermediates", Tetrahedron Letters, 29, (1988), 81-84.
Honda et al., Tetrahedron Letters, pp. 2093-2096 (1981).

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