Process for preparing novel 7-thioester derivatives of 3H pyrrol

Details Process for preparing novel 7-thioester derivatives of 3H pyrrol Process for preparing novel 7-thioester derivatives of 3H pyrrol

1984-11-26

1985-11-05

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548453, C07D24702

Patent

active

045515352

ABSTRACT:
The instantly claimed invention is a process for preparing novel 7-thioether derivatives of 2-aryl, 3 aryl, and 2,3-diary-2,5,7,7-tetra-hydro-3H-pyrrolo [1,2-a] imidazole and 8-thio-ether derivatives of 2-aryl, 3-aryl, and 2,3-diaryl-2,3,5,7,7,8-hexahydro-imidazo [1,2-a]-pyridine which comprises (a) contacting the corresponding amidine with about one molar equivalent of R.sub.1 SSR.sub.1 in the presence of about two molar equivalents of base and at a temperature of -78.degree. C. to about 0.degree. C. (b) contacting the corresponding amidine compound with about two molar equivalents of R,SSR, in the presence of about two molar equivalents of a base and at a temperature of from about -78.degree. C. to about 23.degree. C., said compounds being useful as immunomodulators.

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