Process for preparing nonionic X-ray contrast agents

Details Process for preparing nonionic X-ray contrast agents Process for preparing nonionic X-ray contrast agents

1991-09-24

1993-03-02

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C23312, C07C23316

Patent

active

051911205

ABSTRACT:
Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino-1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2-propanediol are provided.

REFERENCES:
patent: 3290366 (1966-12-01), Hoey
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4396597 (1983-08-01), Rakli
patent: 4396598 (1983-08-01), Lin
patent: 4426371 (1984-01-01), Pfeiffer et al.

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