Process for preparing noncohesive coating layer

Details Process for preparing noncohesive coating layer Process for preparing noncohesive coating layer

1993-01-28

1996-01-02

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

264 43, 264 432, 264 433, 4284022, 514821, A61K 950, B01J 1310, B01J 1322

Patent

active

054806550

ABSTRACT:
A process for producing microcapsules with an adhesive coating layer which comprises forming a slurry of microcapsules in a medium selected from water, one or more organic solvents or a mixture thereof by a coacervation method, adding powders of a pharmaceutically acceptable inorganic compound which is insoluble in the medium to the slurry, so that the inorganic compound adheres to substantially the overall surface of the adhesive coating layer, and separating the microcapsules from the medium.

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patent: 3179600 (1965-04-01), Brockett
patent: 4268411 (1981-05-01), Iwata et al.
patent: 4464317 (1984-08-01), Thies et al.
patent: 4479911 (1984-10-01), Fong
patent: 4703051 (1987-10-01), Adachi et al.
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patent: 5013557 (1991-05-01), Tai
Palmieri, Journal of Pharmaceutical Sciences, vol. 68, No. 12, Dec. 1979, pp. 1561-1562.
Takenaka et al., Journal of Pharmaceutical Science, vol. 69, No. 5, May 1980 pp. 513-516.
Deasy, Marcel Dekker, 1984, pp. 64-81, 89-95.
Ajinomoto et al., Patent Abstracts of Japan, vol. 8, No. 122 (C-227) (1559) Jun. 8, 1984.

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