Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1991-06-26
1993-09-28
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 553, C07H 1909, A61K 4300, A61K 3170
Patent
active
052487717
ABSTRACT:
Reacting [.sup.* X]X- with YVaraU in the presence of a cuprous ion catalyst under anaerobic and reducing conditions produces [.sup.* X]XVaraU, where .sup.* X is a radioactive halogen, Y is a second halogen, X and Y are different halogens, and XVaraU is 1-(.beta.-D-arabinofuranosyl)-5(E)-(2-halogenovinyl) uracil, the halogen of which is X. The reaction produces an effective administrable form of [.sup.* X]XVaraU for use in diagnosis and treatment of herpes virus infections.
REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
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Samuel et al., Int. J. Appl. Radiat. Isot. 35(11): 1049-1052, 1984.
Verbruggen et al. Appl. Radiat. Isot. 37(4): 355-357, 1986.
Robbins et al. J. Med Chem. 34:2275-2280, 1991.
Brown Johnnie R.
Kunz Gary L.
Triumf
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