Process for preparing nizatidine

Details Process for preparing nizatidine Process for preparing nizatidine

1996-05-06

1997-12-23

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548205, C07D27724, C07D27728

Patent

active

057009457

ABSTRACT:
Nizatidine is prepared by a process in which the final step is the reaction of the 2-hydroxymethyl analog of nizatidine, namely tro-1,1-ethenediamine, with excess dimethylamine and an (N,N-dimethylamino)phosphonium halide such as (N,N-dimethylamino) triphenyl-phosphonium bromide. The process yields nizatidine in a very high state of purity.

REFERENCES:
patent: 4468517 (1984-08-01), Lilly
patent: 5574054 (1996-11-01), Kitagawa
"Thiazoles and their Beno Derivatives", J.V. Metzger in Comprehensive Heterocylic Chemistry vo. 6 (Part 4b) Kevin Potts Ed. 1984.
Arakawa, K et al. Chem. Pharm. Bull 20, 1041, (1972).
Babadjamian et al.; J. Heterocyclic Chem; 13 1205 (1976).

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