Process for preparing new thymopentin retro-inverso analogs and

Details Process for preparing new thymopentin retro-inverso analogs and Process for preparing new thymopentin retro-inverso analogs and

1991-01-31

1993-04-06

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530330, 530331, 514 18, 514 19, A61K 3702, C07K 508, C07K 510

Patent

active

052005062

ABSTRACT:
New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. A process of preparing the tripeptide fragment of formula I is also described.
The new compounds are enzyme-resistant immunomodulatory peptides.

REFERENCES:
patent: 4298523 (1981-11-01), Heavner
patent: 4369137 (1983-01-01), Heavner
patent: 4505853 (1985-03-01), Goldstein et al.
patent: 4713367 (1987-12-01), Sisto et al.
patent: 5013723 (1991-05-01), Sisto et al.
patent: 5061811 (1981-10-01), Pinori et al.

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