Process for preparing nevirapine

Details Process for preparing nevirapine Process for preparing nevirapine

1995-01-12

1996-10-29

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D47114

Patent

active

055697607

ABSTRACT:
A process for preparing nevirapine which comprises reacting 2-chloro-N-(2-chloro-4-methyl-3-pyridyl)-3-pyridine carboxamide with cyclopropylamine followed by cyclisation of the product, wherein the reaction with cyclopropylamine is carried out in the presence of an oxide or hydroxide of an element of the second main or sub-group of the periodic table of elements.

REFERENCES:
patent: 5366972 (1994-11-01), Hargrave
Saunders, Drug Design and Discovery, 8, 255-263 (1992).
Karl D. Hargrave et al., J. Med. Chem. 34, 2231-2231 (1991).
M. H. Norman et al., J. Heterocyclic Chem., 30, 771-779 (1993).
Haslir et al., J. Infect Diseases 171, 537 (1995).
Wei, Nature 373, 117 (1995).
O'Brien, New. Eng. J. Medicine 334, 426 (1996).

Affiliated with

Also associated with

Rating

Process for preparing nevirapine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing nevirapine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing nevirapine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1786436