Process for preparing netilmicin

Details Process for preparing netilmicin Process for preparing netilmicin

1986-11-06

1989-05-16

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 136, 536 137, 536 168, 536 185, A61K 3171, C07H 1522, C07D 704

Patent

active

048311235

ABSTRACT:
A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2' positions, and optionally at the 4' position, converting the 1-amino substituent to a 1-N-imino substituent, converting the imino to an ethylamino, deprotecting the compound and recovering netilmicin. Also disclosed are novel intermediate compounds.

REFERENCES:
patent: 4002742 (1977-01-01), Wright et al.
patent: 4020269 (1977-04-01), Hiraga et al.
patent: 4024332 (1977-05-01), Fenner et al.
patent: 4294959 (1981-10-01), Voss et al.
patent: 4335114 (1982-06-01), Voss et al.
patent: 4347354 (1982-08-01), Cron et al.
patent: 4380625 (1983-04-01), Stadler et al.
Nagabhushan et al.; Carbohydrate Research, 130:243-249, (1984).

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