Process for preparing nebivolol

Details Process for preparing nebivolol Process for preparing nebivolol

2011-06-14

2011-06-14

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S405000, C549S407000

Reexamination Certificate

active

07960572

ABSTRACT:
The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.

REFERENCES:
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Chandrasekhar, et al., Enantiomer Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol, vol. 56, No. 34, 2000-08-18, pp. 6339-6344, Tetrahedron, Elsevier Science Publishers, Amsterdam, NL.
Written Opinion of the International Searching Authority issued for the corresponding PCT International Application No. PCT/EP2007/008549.

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