Process for preparing naproxen

Details Process for preparing naproxen Process for preparing naproxen

1987-12-23

1989-09-05

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

562460, C02C 4923

Patent

active

048640638

ABSTRACT:
Process for preparing Naproxen via a sequence of stereospecific reactions which comprises: condensation of 1-chloro-2-methoxy-naphthalene with a (S)-2-halo-propionyl halide according to the Friedel-Crafts reaction, ketalization of the thus obtained (S)-2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)propan-1-one, rearrangement of said ketal to afford an ester, hydrolysis of the ester and removal of the chlorine atom in 5-position by hydrogenolysis.
New (S) 2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)propan-1-ones.

REFERENCES:
Marguet Andre et al, Bull. Soc. Chem France 1962 90-6.

Affiliated with

Also associated with

Rating

Process for preparing naproxen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing naproxen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing naproxen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-244615