Process for preparing N-substituted amino acid esters

Details Process for preparing N-substituted amino acid esters Process for preparing N-substituted amino acid esters

1990-05-09

1991-10-08

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 34, 560 38, 560 39, 560 40, 560155, 560168, 560169, 560173, C07D23364

Patent

active

050555880

ABSTRACT:
A process for preparing N-substituted amino acid esters having the formula (I): ##STR1## wherein R.sub.1 and R.sub.4, the same or different, are an alkyl, aralkyl, cycloalkyl or aryl group; and R.sub.2 and R.sub.3, the same or different,are an alkyl, aralkyl, aryl, heterocycle-alkyl, aminoalkyl or guanidylalkyl, by the reaction of .alpha.-amino acid esters with .alpha.-substituted carboxylic acid esters, under the condition of substantially free from solvent, which can afford their optical isomers in a good yield.

REFERENCES:
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4542234 (1985-09-01), Reilly, Jr. et al.
patent: 4596791 (1986-06-01), Piwinski et al.

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