Process for preparing N.sub.1 -(2'-furanidyl)-5-fluorouracil

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544229, C07D23954

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active

041071620

ABSTRACT:
Process for preparing N.sub.1 -(2'-furanidyl)-5-fluorouracil having effective pharmacological activities such as anti-leukemia and anti-tumor activities comprising reacting 2,4-bis(trialkylsilyl)-5-fluorouracil with 2,3-dihydrofuran in the presence of a proton donor and a catalyst. Such process can be simply, easily conducted to give the desired product having a high purity in good yield.

REFERENCES:
patent: 3912734 (1975-10-01), Giller et al.
patent: 3960864 (1976-06-01), Townsend et al.
patent: 4039546 (1977-08-01), Giller et al.

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