Process for preparing N-pyrrolyl-pyridazineamine derivatives

Details Process for preparing N-pyrrolyl-pyridazineamine derivatives Process for preparing N-pyrrolyl-pyridazineamine derivatives

1981-12-18

1983-05-24

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 60, 544237, 544238, 542417, C07D41314

Patent

active

043851797

ABSTRACT:
The present invention refers to a new process for preparing N-2,3,4,5-substituted-1H-pyrrol-1-yl)-6-substituted amino-3-pyridazineamine, known as antihypertensive agents. The process is characterized in that a suitable 3,6-dihalogenopyridazine is reacted with hydrazine hydrate or other hydrazine derivatives of formula NH.sub.2 NHR, the obtained compound is reacted with a suitable dicarbonyl compound yielding first an alcandione-bis-[6-halogen-3-pyridazininyl]hydrazone, and then a 6-halogen-3-pyrrolylpyridazineamine derivative which is in turn reacted with an amine to yield the desired compounds.

REFERENCES:
Pifferi et al., J. Med. Chem. (1975) vol. 18, No. 7, pp, 741-746.
Castle, Pyridazines, John Wiley (1973), pp. 463-469 & 635-637.
Castle, Condensed Pyridazines Including Cinnolines and Phthalazines, John Wiley (1973), pp. 560-571 & 596-599.

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