Process for preparing N,N-bis(2-hydroxyethyl)benzylamine and N,N

Details Process for preparing N,N-bis(2-hydroxyethyl)benzylamine and N,N Process for preparing N,N-bis(2-hydroxyethyl)benzylamine and N,N

1985-03-06

1988-05-31

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564346, C07C 8520

Patent

active

047482761

ABSTRACT:
Improvements are shown in the successive preparations of N,N-bis(2-hydroxyethyl)benzylamine starting with benzyl chloride, its conversion to the corresponding N,N-bis(2-chloroethyl)benzylamine in substantially quantitative yield in toluene solution and using the latter by reaction with phenylacetonitrile in the presence of aqueous sodium hydroxide solution and a tetra-n-butylammonium salt, preferably the hydrogen sulfate, to produce improved over-all yields of up to over 75% (based on benzyl chloride) of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride, an intermediate for preparing meperidine.

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