Process for preparing n-methyl derivatives of methyl dihydrolyse

Details Process for preparing n-methyl derivatives of methyl dihydrolyse Process for preparing n-methyl derivatives of methyl dihydrolyse

1986-07-10

1988-04-19

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 67, C07D45704

Patent

active

047390611

ABSTRACT:
A process for preparing an N-methyl derivative of methyl dihydrolysergate and methyl methoxylumilysergate, of formula: ##STR1## in which R.sub.1 denotes a hydrogen atom or a methoxy group, which comprises reacting a methylating agent with a compound of formula: ##STR2## in which R.sub.1 is defined as above, in the presence of a quaternary salt, in the presence of a solid metal alcoholate of formula CH.sub.3 --OM in which M denotes an alkali metal atom, or an alkali metal hydride, and in the presence of a dehydrating agent of formula R.sub.2 --COO--CH.sub.3 in which R.sub.2 denotes a hydrogen atom or an alkyl, alkyloxy, alkyloxycarbonyl or aryl group or of formula R.sub.3 --C(OCH.sub.3).sub.3 in which R.sub.3 denotes a hydrogen atom, an alkyl group or an aryl group.

REFERENCES:
patent: 3113133 (1963-12-01), Hofmann et al.
patent: 3228940 (1966-01-01), Bosisio et al.
patent: 3228941 (1966-01-01), Bernardi et al.
patent: 3228943 (1966-01-01), Bernardi et al.
patent: 3879554 (1975-04-01), Temperilli
patent: 4230859 (1980-10-01), Rucman
patent: 4232157 (1980-11-01), Enrico
Erico, CA 93-150450f.
Troxler et al., Helv. Chem. Acta, 40, 1721, (1957).
Societa Farmaceutici Italia, CA; vol. 61, (1964), 1907a.
Barry et al., CA 98-197579y, (1983).

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