Process for preparing N-methyl derivatives of lysergol and 10.al

Details Process for preparing N-methyl derivatives of lysergol and 10.al Process for preparing N-methyl derivatives of lysergol and 10.al

1989-03-27

1990-03-13

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 68, 546 69, C07D45702

Patent

active

049084496

ABSTRACT:
A process for preparing 1-methyllysergol or 10.alpha.-methoxy-1-methyllumilysergol, which comprises adding a base, which is an alkali metal hydride or alcoholate, to a solution of lyergol or 10.alpha.-methoxylumilysergol in a polar aprotic solvent in such a way that the molecular ratio between the base and the lysergol or 10.alpha.-methoxylumilysergol remains less than 0.5:1, and then adding a methylating agent which is methyl iodide, methyl sulphate or trimethylsulphonium iodide.

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patent: 3879554 (1975-04-01), Temperilli
patent: 4232157 (1980-11-01), Enrico
patent: 4734501 (1988-03-01), Marzoni
patent: 4754037 (1988-06-01), Gervais
patent: 4772709 (1988-09-01), Marzoni

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