Process for preparing N-methyl-3-(P-trifluoromethylphenoxy)-3-ph

Details Process for preparing N-methyl-3-(P-trifluoromethylphenoxy)-3-ph Process for preparing N-methyl-3-(P-trifluoromethylphenoxy)-3-ph

1997-07-07

1998-12-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21306, C07C21748

Patent

active

058472142

ABSTRACT:
The present invention relates to a process for preparing N-methyl-3-(p-trifluoromethylphenoxy)-3-phenyl-propylamine and pharmaceutically acceptable acid addition salts thereof. The process in accordance with the present invention comprises reacting 1-phenyl-3-(N-methylamine) propane-1-ol with 1-chloro-4-trifluoromethylbenzene, in the presence of an hydroxide of an alkaline metal in a dipolar aprotic solvent non saponifiable in reaction conditions. The process in accordance with the present invention further comprises a final crystallization step which allows to obtain the active ingredient in a highly pure crystalline form.

REFERENCES:
patent: 4314081 (1982-02-01), Molloy et al.
patent: 5166437 (1992-11-01), Kairisalo et al.
patent: 5618968 (1997-04-01), Crnic et al.

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