Process for preparing N-demethyl-N-alkyl erythromycin derivative

Details Process for preparing N-demethyl-N-alkyl erythromycin derivative Process for preparing N-demethyl-N-alkyl erythromycin derivative

1998-05-15

2000-07-04

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 185, C07H 100, C07H 1708

Patent

active

06084079&

ABSTRACT:
The claimed invention relates to a novel process of preparing N-demethyl-N-alkyl-4"-deoxy erythromycin A and B. The process comprises protecting the 2'-hydroxy or the 2'- and 11-hydroxy of a N-demethyl-4"-deoxy erythromycin derivative having the formula: ##STR1## where R.sub.b is H or OH, with a silyl protecting group and alkylating the N-position of the desosamine sugar.

REFERENCES:
patent: 3725385 (1973-04-01), Freiberg
patent: 5578579 (1996-11-01), Lartey et al.
patent: 5760198 (1998-06-01), Parekh et al.
P.A. Lartey, et al., J. Med. Chem., 38 (1793-1798 1995); "Synthesis of 4"--.backslash. Deoxy Motilides: Identification of a Potent and Orally Active Prokinetic Drug Candidate.

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