Process for preparing N-aryl-N'-alkyl-piperazines

Details Process for preparing N-aryl-N'-alkyl-piperazines Process for preparing N-aryl-N'-alkyl-piperazines

1998-07-24

1999-07-13

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D29513, C07D295096, C07D295088, C07D295073

Patent

active

059228741

ABSTRACT:
N-aryl-N'-alkyl-piperazines are obtained in a particularly simple manner, in good yields and in short reaction times when an aniline is reacted under pressure with an N-alkyl-bishydroxyethyl-amine in the presence of a strong acid.

REFERENCES:
patent: 2830056 (1958-04-01), Ruschig et al.
patent: 3106557 (1963-10-01), Poppelsdorf et al.
patent: 3326916 (1967-06-01), Creighton et al.
patent: 3381009 (1968-04-01), Palazzo et al.
patent: 3637705 (1972-01-01), Horrom et al.
Batson, F.M. and C.A. Kraus. "A New Synthesis of N-Monophenylpiperazine." Journal of the American Chemical Society, 56(10), 2199-2200 (1934), Oct. 1934.
C. Kremer, "A New Synthesis of N-Phenylpiperazino-N-Beta-Ethanol", J. Am. Chem. Soc., vol. 58, 379 (1936).
Prelog, V and V. Stepan. "Nouvelle Synthese des Piperazines N-monalcoylees" French!.

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