Process for preparing N-acylcarnosine

Details Process for preparing N-acylcarnosine Process for preparing N-acylcarnosine

1981-12-09

1983-06-07

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

043872328

ABSTRACT:
A new process is disclosed for preparing N-acylcarnosine which comprises reacting histidine with 3-acylaminopropionic acid reactive derivatives under basic conditions, and 3-acylaminopropionic acid reactive derivative being acid chloride, mixed acid anhydride salt with sulfuric acid, mixed acid anhydride with mono alkyl carbonate or mixed acid anhydride with phosphoric acid derivatives.

REFERENCES:
March, J. Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 335, 336 and 339.
Lukton, A., et al., J. Org. Chem., 26, 617, (1961), [C.A. 55, 16520a, (1961)].

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