Process for preparing N-acylated 4-hydroxypenylamine derivatives

Details Process for preparing N-acylated 4-hydroxypenylamine derivatives Process for preparing N-acylated 4-hydroxypenylamine derivatives

1995-09-18

1997-04-15

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27506

Patent

active

056211104

ABSTRACT:
The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group of formula I: ##STR1## in which n is a number from 1 to 5, and to processes for preparing these derivatives and to pharmaceutical compositions containing said derivatives; these compounds possess high analgesic activity free from antipyretic activity, and they display little hepatotoxic effect.

REFERENCES:
patent: 4116964 (1978-09-01), Zinnes et al.
Hsi et al., J. Labelled Compd. Radiopharm. (1989), 27(3), 287-95.
Easton et al., J. Chem. Soc., Perkin Trans. 1(1990), (2), 277-82.
D'Amico et al., J. Heterocycl. Chem. (1988), 25(4), 1183-90.

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