Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiaz

Details Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiaz Process for preparing N"-[4-[[(2-cyanoethyl)thio]methyl]-2-thiaz

1988-04-08

1990-07-17

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27748

Patent

active

049422430

ABSTRACT:
A process for preparing N"-[4-[[(2-cyanoethyl)thiol]methyl]-2-thiazolyl]guanidine which comprises reacting a dihaloacetone with an .beta.-cyanoethylthiol in a two phase solvent system at a pH of 4.5-6.0 to produce a 1-halo-3-(2-cyanoethylthio)propanone and reacting the 1-halo-3-(2-cyanoethylthio) with an amidinothiourea.

REFERENCES:
patent: 4464374 (1984-08-01), Yellin
patent: 4762932 (1988-08-01), Yellin
Starks, Phase Transfer Catalysis pp. 80-84 (1978).
Dehmlow, Phase Transfer Catalysis pp. 138-140 (1980).

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