Process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-a

Details Process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-a Process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-a

1986-08-25

1987-12-29

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20709

Patent

active

047162350

ABSTRACT:
A process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline, which comprises reacting N-carboxyanhydride of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine with L-proline in the presence of a base. According to the process, enalapril can be prepared economically, easily and effectively.

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patent: 4496542 (1985-01-01), Skiles et al.
Wyvratt, et al.; J. Org. Chem.; 49; (1984); pp. 2816-2819.
Kaltenbronn, et al.; Organic Preparations & Procedures Intl., 15 (1982); pp. 35-40.
Katritzky, et al.; "Comprehensive Heterocyclic Chemistry"; vol. 6; Part 4B (1948); pp. 214-215; Pergamon Press-Oxford, N.Y.

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