Process for preparing monobactames and their intermediate produc

Details Process for preparing monobactames and their intermediate produc Process for preparing monobactames and their intermediate produc

1993-05-11

1993-10-19

Page, Thurman K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D20108

Patent

active

052546810

ABSTRACT:
There is described a process for preparing monobactames of formula: ##STR1## where R=acyl, and their pharmaceutically acceptable salts, starting from ethyl (S)-3-hydroxybutanoate through the reaction intermediate (3S, 4R)-3-hydrazino-4-methyl-2-oxo-1-azetidine sulfonic acid or a salt thereof. This intermediate is new and therefore represents a further object of the present invention.

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Cimarusti et al, Med. Res. Reviews, vol. 4, No. 1, 1-24 (1984).
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Sykes et al, Nature, vol. 291, Jun. 11, 1981.
Imada et al, Nature, vol. 289, Feb. 12, 1981.
Cimarusti et al, Tetrahedron, vol. 39, No. 15, pp. 2577-2589, 1983.

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