Process for preparing modified proteins

Details Process for preparing modified proteins Process for preparing modified proteins

1994-09-26

1998-12-29

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530335, 530336, 530345, 530332, C07K 104

Patent

active

058543899

ABSTRACT:
Process for the preparation of modified proteins comprising the coupling of a first peptide segment having a haloacyl group at the N-terminus thereof with a second peptide segment having a carbonylthiol group at the C-terminus thereof are disclosed. Novel modified proteins produced by the process are also disclosed.

REFERENCES:
patent: 4946839 (1990-08-01), Kozikowskip
patent: 4990504 (1991-02-01), Kozikowski
patent: 5066716 (1991-11-01), Robey
patent: 5286846 (1994-02-01), Inman
patent: 5371197 (1994-12-01), Marburg
patent: 5453269 (1995-09-01), Haber
patent: 5484722 (1996-01-01), Friesen
Yamashiro, Int. J. Peptide Prot Res 31, 322 1988.
Mc Rae, Biochemistry 20, 7196, 1981.
Spatola, Biochem Biophys Res Comm 97, 1014, 1980.
R.E. Offord, "Protein Engineering by chemical means?" Protein Engineering, vol. 1, No. 3, pp. 151-157 (1987).
F.A. Robey, et al., "Automated Synthesis of N-Bromoacetyl-Modified Peptides for the Preparation of Synthetic Peptide Polymers, Peptide-Protein Conjugtes, and Cyclic Peptides," Analytical Biochemistry 177, 373-377 (1989).
Spatola "Peptide Bond Modifications . . ." Chem & Biochem of A.A., peptides & Proteins (1983) 267-357.
Carruthers Some Modern Methods of Ong Syn pp. 101, 102, 338, 1978.

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