Process for preparing microspheres for the prolonged release of

Details Process for preparing microspheres for the prolonged release of Process for preparing microspheres for the prolonged release of

1993-07-27

1996-07-30

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424501, A61K 914, A61K 950

Patent

active

055409377

ABSTRACT:
Process for preparing microspheres for the prolonged release of the LHRH hormone and of its analogues, the hormone being dispersed in a water-insoluble polymer or copolymer matrix, the solvent evaporation process is characterized by the use of a pair of organic solvents of which one makes it possible more specifically to obtain a homogeneous suspension of the hormone in the pulverulent state by simply stirring and of which the other is slightly water-miscible so as to allow more specifically the microdispersion of the organic phase in the aqueous phase in which the hardening of the microspheres is performed. This process leads to the preparation of LHRH-containing microspheres which are noteworthy for their purity, especially to microspheres with complex matrices, as well as to formulations comprising at least two types of microspheres.

REFERENCES:
patent: 3523906 (1970-08-01), Vrancken et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3773919 (1973-11-01), Boswell et al.
patent: 3887699 (1975-06-01), Yolles
patent: 3891570 (1975-06-01), Fukushima et al.
patent: 3960757 (1976-06-01), Morishita et al.
patent: 4389330 (1983-06-01), Tice et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4542025 (1985-09-01), Tice et al.
patent: 4673595 (1987-06-01), Orsolini et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4818542 (1989-04-01), Deluca et al.
patent: 4835139 (1989-05-01), Tice et al.
patent: 4897268 (1990-01-01), Tice et al.
patent: 4935245 (1990-06-01), Horn et al.
patent: 5100669 (1992-03-01), Hyan et al.
patent: 5192741 (1993-03-01), Orsolini et al.
Bodmeier et al, "The preparation and evaluation of drug-containing . . . ", Pharmaceutical Research, vol. 4, No. 6, 1987, pp. 465-471.
Bodmeier et al, "Polylactic acid microspheres containing quinidine . . . ", J. Microencapsulation, 1987, vol. 4, No. 4, pp. 289-297.
Ogawa et al, "A new technique to efficiently entrap leuprolide acetate . . . ", Chem Pharm Bull, No. 3, pp. 1095-1103.
Heya et al, "Effects of counteranion of TRH and loading amount . . . ", International Journal of Pharmaceutics, vol. 69, 1991 pp. 69-75.
Bodmer et al, "Sustained release of the somatostatin analogue . . . ", Proceed. Intern. Symp. Control. Rel. Bioact. Mater., vol. 18, 1991, pp. 597-598.
Chang, "Biodegradable semipermeable microcapsules containig enzymes . . . ", Journal of Bioengineering, vol. 1, 1976, pp. 25-32.
Tice et al, "3-month and 6-month delivery of peptides (LHRH) from . . . ", Proceed. Intern. Symp. Control. Rel. Bioact. Mater., vol. 18, 1991, pp. 467-468.
Burns et al, "Nafarelin controlled release injectible: theoretical . . . ", J. Microencapsulation, 1990, vol. 7, No. 3, pp. 397-413.
Cowsar et al, "Poly(lactide-co-glycolide) microcapsules for controlled release of steroids", Methods in Enzymology, vol. 112, 1985, pp. E82-E97.

Affiliated with

Also associated with

Rating

Process for preparing microspheres for the prolonged release of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing microspheres for the prolonged release of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing microspheres for the prolonged release of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1656576