Process for preparing melanogenic inhibitor, and pigmentation-li

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Tissue – other than lymphoid tissue

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A61K 3512, A61K 740

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active

050770594

ABSTRACT:
The present invention relates to a process for preparing a melanogenic inhibitor and a pigmentation-lightening agent containing the same, more particularly, the present invention relates to a process for preparing a novel melanogenic inhibitor which is obtained by proliferating an established cell line from a warm-blooded animal, homogenizing the proliferated cells and recovering the same from the resultant homogenate, as well as to a pigmentation-lightening agent containing the same.

REFERENCES:
Sigi et al, "Inhibition of DNA and Protein Synthesis in Melanocytes by a Melanoma Extract" CA80:131386, 1974.
Ishikawa, Kebal "Inhibition of Aminoacyl-Transfer RNA Formation by Low-Molecular Substances from Melanoma Extract", CA100:116579, 1984.
Ohyama, Y. "Topical Agents for Inhibiting Melanin Generation" CA107:12943, 1987.
J Cell Physiol 137 (1), 1988-35-44 Kameyama K; Montague P M; Hearing VJ.
Isolation and Characterization of Tyrosinase Inhibitors and their Differential Action on Melanogenic Subcellular Compartments in Amelanotic and Melanotic Melanomas; British Journal of Dermatology (1980); 625-633 Imokawa G and Mishima Y.
Loss of Melanogenic Properties in Tyrosinases Induced by Glycosylation Inhibitors within Malignant Melanoma Cells; Cancer Research vol. 42 (1982) 1994-2002.
GERL-Coated Vesicle System in the Melanin Synthesizing Cell: Its three-Dimensional Ultrastructure and Tyrosinase Activity, Nippon Hifuka Gakkai Zasshi (1977) 87(13) 883-901.

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