Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1983-05-16
1985-05-21
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
A61K 3578
Patent
active
045185921
ABSTRACT:
A process for preparing mangiferin from plants of the genus of Hedysarum (Hedysarum alpinum L., Hedysarum flavescens Rgl. et Schmalh) comprising extraction of xanthone glycosides from the aerial portion of the plants by means of a mixture acetone-water at a volume ratio of the mixture components of 1:0.5-2 respectively; the resulting extract is evaporated, the evaporated extract is filtered. To the filtered evaporated extract sulphuric acid is added to a pH of from 2 to 4, heated at reflux and filtered. The thus-prepared extract is treated with a non-polar organic solvent with the formation of two layers, wherefrom the upper aqueous layer contains xanthone glycosides. This upper layer is treated with butanol with the formation of two layers, wherefrom the upper layer comprises a solution of xanthone glycosides in butanol. This upper butanolic layer is evaporated. The precipitated mangiferin is separated and recrystallized.
REFERENCES:
patent: 3772269 (1973-11-01), Lew
Komarov, Flora of the USSR, 1948, Izdatelstvo Akademii Naak SSSR Pub., pp. _278-279.
British Pharmacopoeia, 1980, vol. 2, pp. 561-565.
Ananieva Alla A.
Glyzin Vladimir I.
Kocherga Stepan I.
Libizova Larisa F.
Rusakova Svetlana V.
Meyers Albert T.
Rollins Jr. John W.
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