Process for preparing macrocyclic compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C540S546000, C548S537000

Reexamination Certificate

active

07148347

ABSTRACT:
Disclosed is a process for preparing a macrocyclic compound of the formula (I):which is carried out using an intermediate of the formula (II):wherein W, R1through R4, D, A and R12are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

REFERENCES:
patent: 6323180 (2001-11-01), Llinas-Brunet et al.
patent: 6534523 (2003-03-01), Llinas-Brunet
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 2004/0248779 (2004-12-01), Dersch et al.
patent: 2005/0080005 (2005-04-01), Llinas-Brunet et al.
patent: WO 00/09543 (2000-02-01), None
patent: WO 00/09558 (2000-02-01), None
patent: WO 00/59929 (2000-10-01), None
Llinas-Brunet, M. et al; “Macrocyclic Peptides Active Against The Hepatitis C Virus”; U.S. Appl. No. 10/686,755, filed Oct. 16, 2003.

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