Process for preparing lysergol derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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20415771, C07D45704

Patent

active

048701793

ABSTRACT:
A method of preparing lysergol derivatives, particularly 10.alpha.-methoxy lumilysergol, 1-methyl-10.alpha.-methoxy-lumilysergol and C8 esters of 1-methyl-10.alpha.-methoxy-lumilysergol, is provided characterized in that lysergol esters are subjected to photo-chemical reaction in methanol/sulphuric acid to form esters of 10.alpha.-methoxy lumilysergol. The esters can be subsequently hydrolyzed to obtain 10.alpha.-methoxy-lumilysergol, or can be transesterified with salts of other acids and/or N-methylated.

REFERENCES:
patent: 3228943 (1906-01-01), Bernardi et al.
patent: 3585201 (1971-06-01), Arcamone
patent: 3647655 (1972-03-01), Bernardi et al.
patent: 3879554 (1975-04-01), Temperilli
patent: 4232157 (1980-11-01), Enrico

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