Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...
Patent
1984-03-08
1986-08-26
Lovering, Richard D.
Plastic and nonmetallic article shaping or treating: processes
Encapsulating normally liquid material
Liquid encapsulation utilizing an emulsion or dispersion to...
222 94, 2221463, 222635, 252305, 424 38, 4284022, 436829, B01J 1302, A61K 950, A61K 964
Patent
active
046082115
ABSTRACT:
A process for preparing large unilamellar lipid vesicles is disclosed which process comprises preparing unilamellar lipid vesicles having an average diameter of at least 1,000 .ANG., each of these vesicles consisting of a spheroidal lipid lamella containing a substance to be encapsulated, which process comprises dissolving one or more lipids intended to form the lamella of the vesicles in at least one water-insoluble solvent, conditioning the resulting lipid solution at a pressure P.sub.1 and at a temperature .theta..sub.1, dissolving the substance to be encapsulated in water to obtain an aqueous phase, conditioning said aqueous phase at a pressure P.sub.2 and a temperature .theta..sub.2, injecting the lipid solution into the aqueous phase at a low flow rate so as initially to form droplets and so that solvent of the lipid solution vaporises on coming into contact with the said aqueous phase, the pressure P.sub.2 being less than P.sub.1 and less than the vapor pressure of the solvent in the said droplets at the temperature .theta..sub.2.
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Puisieux et al. "Les Liposomes, Vehicules Possibles De Principes Actifs", Pharm. Acta. Helv., 52, Nr. 12 (1977), pp. 305-318.
Handjani Rose-Marie
Maurelli Manlio M.
Ribier Alain
"L'Oreal"
Lovering Richard D.
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