Process for preparing L-carnitine and chemical intermediates emp

Details Process for preparing L-carnitine and chemical intermediates emp Process for preparing L-carnitine and chemical intermediates emp

1984-02-15

1987-12-01

Warden, Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435141, C12P 762, C12P 752

Patent

active

047104686

ABSTRACT:
A process for preparing L-carnitine which comprises exposing .gamma.-substituted acetoacetic acid esters or amides to the fermentative enzymatic action of a microorganism which elaborates L-.beta.-hydroxyacyl CoA dehydrogenase [EC 1.1.1.35] , recovering the resulting, optically active corresponding .gamma.-substituted-.beta.-hydroxybutyric acid derivative and converting said derivative to L-carnitine. An improvement in the process is also disclosed which comprises reacting a 4-chloro-3(R)-hydroxybutyrate with sodium iodide or bromide to produce the corresponding 4-iodo- or 4-bromo-3(R)-hydroxybutyrate, converting the 4-iodo- or 4-bromo-3(R)-hydroxybutyrate to the trimethylamino-3(R)-hydroxybutyrate salt, then converting the trimethylamino-3(R)-hydroxybutyrate salt into L-carnitine. Novel chemical intermediates prepared in the processes are also disclosed.

REFERENCES:
patent: 3823069 (1974-07-01), Miyaki
patent: 3925156 (1975-12-01), Chang et al.
patent: 4211846 (1980-07-01), Lafferty
patent: 4371618 (1983-02-01), Cavazza
Nakamura et al, Tetrahedron Letters, vol. 25, No. 36, (1984), pp. 3979-3982.
Fuganti et al, Tetrahedron Letters, vol. 26, No. 1, (1985), pp. 101-104.
Seebach et al, Angew. Chem. Int. Ed. Engl., vol. 23, (1984), No. 2, pp. 151-152.
Morrison et al, Organic Chemistry, Third Edition, Boston, Allyn and Bacon, Inc., 1973, p. 1089.
Chemical Abstracts, vol. 84, 1976, Abstract No. 59999, Tenud.
Mori, Tetrahedron, vol. 37, (1981), pp. 1341-1342.
Limieux et al, Can. J. Chem., vol. 29, (1951), pp. 678-690.
Schweizer et al, Pro. Nat. Acad. Sci., 67:2, (1970), pp. 660-666.
Kuhn et al, Euro. J. Biochem., 24, (1972), pp. 492-497.
Block et al, Acta Chemica Scandinavica, B, 37(4), 1983, pp. 341-344.
Chemical Abstracts, vol. 99, 1983, Abstract No. 103632f, Zhou et al.
S. Deol et al., Aust. J. Chem., (1976), 29, 2459.
Chem. Abstr., 78, (1973), 147382v.
Chem. Abstr., 75, (1971), 19716h.
Frater, Helvetica Chimica Acta, vol. 62, (1979), pp. 2829-2832.
Hirama et al, J. Am. Chem. Soc., vol. 104, (1982), pp. 4251-4253.
Zhou et al, J. Am. Chem. Soc., vol. 105, pp. 5925-5926, (1983).
Hirama et al, J. Chem. Soc., Chem. Commun., (1983), pp. 599-600.
Lynen, "Yeast Fatty Acid Synthase", In: Methods in Enzymology, vol. 14, (1969), pp. 17-33.
Enzyme Nomenclature, Elsevier Scientific Publishing, Amsterdam, (1973), pp. 46-47.
Barman, Enzyme Handbook, vol. 1, Springer-Verlag, New York, (1969), p. 55.

Affiliated with

Also associated with

Rating

Process for preparing L-carnitine and chemical intermediates emp does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing L-carnitine and chemical intermediates emp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing L-carnitine and chemical intermediates emp will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1931316