Process for preparing L-.alpha.-methylphenyl alanines

Details Process for preparing L-.alpha.-methylphenyl alanines Process for preparing L-.alpha.-methylphenyl alanines

1982-05-07

1984-04-17

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435108, C07B 1902, C12P 1322

Patent

active

044435487

ABSTRACT:
Biochemical optical resolution of DL-.alpha.-methylphenyl alanines in which DL-.alpha.-methylphenyl alanine amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-.alpha.-methylphenyl alanines having the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be independently a hydrogen atom or lower alkyl groups, or R.sub.1 and R.sub.2 may be alkylene groups combined together to form 5 through 8-membered rings is produced by the steps of:

REFERENCES:
patent: 4260684 (1981-04-01), Schutt
patent: 4366250 (1982-12-01), Jallageas et al.
Derwent Abstract 77260A/43 of Japanese Patent 53-107,481 (9/19/78).
Methods in Enzymology vol. XVII B pp. 652-656 (1971).
Chemical Abstracts vol. 62: 15998e (1965).

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