Process for preparing isomers of salbutamol

Details Process for preparing isomers of salbutamol Process for preparing isomers of salbutamol

2006-02-07

2006-02-07

Trinh, Ba K. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S304000, C564S356000, C564S363000, C562S585000

Reexamination Certificate

active

06995286

ABSTRACT:
A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol or of said precursor with either (L) or (D) tartaric acid, and where necessary converting said isomer of said precursor into either (R or (S) salbutamol respectively; then optionally converting said optically pure (R) and/or (S) salbutamol into a pharmaceutically acceptable salt.

REFERENCES:
patent: 5545745 (1996-08-01), Gao et al.
patent: 1273966 (2000-11-01), None
patent: 02085247 (1990-03-01), None
patent: 9532178 (1995-11-01), None
patent: 9942460 (1999-08-01), None
Chemical Abstracts, vol. 135, No. 7, Aug. 13, 2001; abstract No. 92436d, p. 775, col. 2; XP002189988.
Patent Abstract of Japan, vol. 014, No. 280, Jun. 18, 1990.

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