Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-10-15
1995-08-15
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 185, 536 186, C07H 100
Patent
active
054420474
ABSTRACT:
An improved process for converting gentamicin B to isepamicin comprising forming 3,6'-di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylating agent, 2-formylmercaptobenzothiazole, and intermediate compounds are also disclosed.
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Chiu John S.
Colon Cesar
Green Michael D.
Tann Chou-Hong
Thiruvengadam Tiruvettipuram K.
Lee, Jr. Warrick E.
Majka Joseph T.
Mazer Edward H.
Peselev Elli
Robinson Douglas W.
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