Process for preparing iodovinyl-estradiol

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424 11, 424 9, A61K 4900, A61K 4300, C07J 300

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active

045419574

ABSTRACT:
17.alpha.-[(E)-2-Iodovinyl]-estra-1,3,5(10)-triene-3,17.beta.-diol wherein the iodine atom is radioactive can be produced from (E)-[3-acyloxy-17.beta.-hydroxyestra-1,3,5(10)-triene-17.alpha.-yl]vinyl dihydroxyborane in an excellent yield by iodinating the same and hydrolyzing the resulting 3-acyloxy-17.alpha.-[(E)-2-iodovinyl]-estra-1,3,5(10)-triene-17.beta.-ol.

REFERENCES:
patent: 4450149 (1984-05-01), Kabalka et al.
Hanson et al., Abstr. Pap. Am. Chem. Soc., 182, (1981), NUCL 56.
Hanson et al., From Nuclear Medicine and Biology Advances, Ed. C. Raynaud, Pergamon Press, Oxford, pp. 3200-3203.
Kabalka et al., Chem. Abst., 98, (1983), #89725j.
Hanson et al., Chem. Abst., 97, (1982), #177890a.

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